Endocrine Abstracts

Introduction: Our endocrine service introduced a nurse led parathyroid clinic to provide an efficient pathway for patients referred with hypercalcaemia.This benefits patients and clinical staff.Materials/Methods: Patients referred with a raised calcium level are vetted by the endocrine consultants and directed to the nurse led clinic. The patients are seen within 6 weeks using a standard proforma and checklist. Relevant investigations to include renal fu...

Heavy menstrual bleeding (HMB) is common and debilitating but it remains a taboo subject. Hence its cause remains undefined, resulting in non-specific hormone therapies with intolerable side effects.Over 70 years ago it was proposed that progesterone withdrawal caused intense vasoconstriction and a transient endometrial hypoxia that resulted in menstruation. Subsequent research confirmed that inflammation initiated menses and disputed the role of hypoxia...

Heavy menstrual bleeding (HMB) is common and debilitating but it remains a taboo subject. Hence its cause remains undefined, resulting in non-specific hormone therapies with intolerable side effects.Over 70 years ago it was proposed that progesterone withdrawal caused intense vasoconstriction and a transient endometrial hypoxia that resulted in menstruation. Subsequent research confirmed that inflammation initiated menses and disputed the role of hypoxia...

Introduction: Heavy menstrual bleeding (HMB) affects over 1 million women in the UK. At menses, progesterone (P4) withdrawal drives inflammation, tissue break-down and repair of the endometrium. Glucocorticoids are mediators of inflammation and angiogenesis. Our previous studies have demonstrated that differential endometrial expression of the glucocorticoid-metabolising enzymes, 11β-HSD-1 and -2, may play a role in HMB. We hypothesise that aberrant lo...